diff -uar Python-3.5.1.orig/Lib/distutils/command/install.py Python-3.5.1/Lib/distutils/command/install.py
--- Python-3.5.1.orig/Lib/distutils/command/install.py	2015-12-07 03:39:07.000000000 +0200
+++ Python-3.5.1/Lib/distutils/command/install.py	2015-12-14 21:27:46.083400395 +0200
@@ -29,15 +29,15 @@
 
 INSTALL_SCHEMES = {
     'unix_prefix': {
-        'purelib': '$base/lib/python$py_version_short/site-packages',
-        'platlib': '$platbase/lib/python$py_version_short/site-packages',
+        'purelib': '$base/lib64/python$py_version_short/site-packages',
+        'platlib': '$platbase/lib64/python$py_version_short/site-packages',
         'headers': '$base/include/python$py_version_short$abiflags/$dist_name',
         'scripts': '$base/bin',
         'data'   : '$base',
         },
     'unix_home': {
-        'purelib': '$base/lib/python',
-        'platlib': '$base/lib/python',
+        'purelib': '$base/lib64/python',
+        'platlib': '$base/lib64/python',
         'headers': '$base/include/python/$dist_name',
         'scripts': '$base/bin',
         'data'   : '$base',
diff -uar Python-3.5.1.orig/Lib/distutils/sysconfig.py Python-3.5.1/Lib/distutils/sysconfig.py
--- Python-3.5.1.orig/Lib/distutils/sysconfig.py	2015-12-07 03:39:07.000000000 +0200
+++ Python-3.5.1/Lib/distutils/sysconfig.py	2015-12-14 21:27:46.083400395 +0200
@@ -133,7 +133,7 @@
 
     if os.name == "posix":
         libpython = os.path.join(prefix,
-                                 "lib", "python" + get_python_version())
+                                 "lib64", "python" + get_python_version())
         if standard_lib:
             return libpython
         else:
diff -uar Python-3.5.1.orig/Lib/site.py Python-3.5.1/Lib/site.py
--- Python-3.5.1.orig/Lib/site.py	2015-12-07 03:39:08.000000000 +0200
+++ Python-3.5.1/Lib/site.py	2015-12-14 21:27:46.083400395 +0200
@@ -303,7 +303,7 @@
         seen.add(prefix)
 
         if os.sep == '/':
-            sitepackages.append(os.path.join(prefix, "lib",
+            sitepackages.append(os.path.join(prefix, "lib64",
                                         "python" + sys.version[:3],
                                         "site-packages"))
         else:
diff -uar Python-3.5.1.orig/Lib/sysconfig.py Python-3.5.1/Lib/sysconfig.py
--- Python-3.5.1.orig/Lib/sysconfig.py	2015-12-07 03:39:08.000000000 +0200
+++ Python-3.5.1/Lib/sysconfig.py	2015-12-14 21:27:46.084400429 +0200
@@ -20,10 +20,10 @@
 
 _INSTALL_SCHEMES = {
     'posix_prefix': {
-        'stdlib': '{installed_base}/lib/python{py_version_short}',
-        'platstdlib': '{platbase}/lib/python{py_version_short}',
-        'purelib': '{base}/lib/python{py_version_short}/site-packages',
-        'platlib': '{platbase}/lib/python{py_version_short}/site-packages',
+        'stdlib': '{installed_base}/lib64/python{py_version_short}',
+        'platstdlib': '{platbase}/lib64/python{py_version_short}',
+        'purelib': '{base}/lib64/python{py_version_short}/site-packages',
+        'platlib': '{platbase}/lib64/python{py_version_short}/site-packages',
         'include':
             '{installed_base}/include/python{py_version_short}{abiflags}',
         'platinclude':
@@ -32,10 +32,10 @@
         'data': '{base}',
         },
     'posix_home': {
-        'stdlib': '{installed_base}/lib/python',
-        'platstdlib': '{base}/lib/python',
-        'purelib': '{base}/lib/python',
-        'platlib': '{base}/lib/python',
+        'stdlib': '{installed_base}/lib64/python',
+        'platstdlib': '{base}/lib64/python',
+        'purelib': '{base}/lib64/python',
+        'platlib': '{base}/lib64/python',
         'include': '{installed_base}/include/python',
         'platinclude': '{installed_base}/include/python',
         'scripts': '{base}/bin',
@@ -61,10 +61,10 @@
         'data': '{userbase}',
         },
     'posix_user': {
-        'stdlib': '{userbase}/lib/python{py_version_short}',
-        'platstdlib': '{userbase}/lib/python{py_version_short}',
-        'purelib': '{userbase}/lib/python{py_version_short}/site-packages',
-        'platlib': '{userbase}/lib/python{py_version_short}/site-packages',
+        'stdlib': '{userbase}/lib64/python{py_version_short}',
+        'platstdlib': '{userbase}/lib64/python{py_version_short}',
+        'purelib': '{userbase}/lib64/python{py_version_short}/site-packages',
+        'platlib': '{userbase}/lib64/python{py_version_short}/site-packages',
         'include': '{userbase}/include/python{py_version_short}',
         'scripts': '{userbase}/bin',
         'data': '{userbase}',
diff -uar Python-3.5.1.orig/Makefile.pre.in Python-3.5.1/Makefile.pre.in
--- Python-3.5.1.orig/Makefile.pre.in	2015-12-07 03:39:09.000000000 +0200
+++ Python-3.5.1/Makefile.pre.in	2015-12-14 21:27:46.084400429 +0200
@@ -125,7 +125,7 @@
 MANDIR=		@mandir@
 INCLUDEDIR=	@includedir@
 CONFINCLUDEDIR=	$(exec_prefix)/include
-SCRIPTDIR=	$(prefix)/lib
+SCRIPTDIR=	$(prefix)/lib64
 ABIFLAGS=	@ABIFLAGS@
 
 # Detailed destination directories
diff -uar Python-3.5.1.orig/Modules/getpath.c Python-3.5.1/Modules/getpath.c
--- Python-3.5.1.orig/Modules/getpath.c	2015-12-07 03:39:10.000000000 +0200
+++ Python-3.5.1/Modules/getpath.c	2015-12-14 21:27:46.085400463 +0200
@@ -118,8 +118,8 @@
 #endif
 
 #ifndef PYTHONPATH
-#define PYTHONPATH PREFIX "/lib/python" VERSION ":" \
-              EXEC_PREFIX "/lib/python" VERSION "/lib-dynload"
+#define PYTHONPATH PREFIX "/lib64/python" VERSION ":" \
+              EXEC_PREFIX "/lib64/python" VERSION "/lib-dynload"
 #endif
 
 #ifndef LANDMARK
@@ -511,7 +511,7 @@
     _pythonpath = Py_DecodeLocale(PYTHONPATH, NULL);
     _prefix = Py_DecodeLocale(PREFIX, NULL);
     _exec_prefix = Py_DecodeLocale(EXEC_PREFIX, NULL);
-    lib_python = Py_DecodeLocale("lib/python" VERSION, NULL);
+    lib_python = Py_DecodeLocale("lib64/python" VERSION, NULL);
 
     if (!_pythonpath || !_prefix || !_exec_prefix || !lib_python) {
         Py_FatalError(
@@ -700,7 +700,7 @@
     }
     else
         wcsncpy(zip_path, _prefix, MAXPATHLEN);
-    joinpath(zip_path, L"lib/python00.zip");
+    joinpath(zip_path, L"lib64/python00.zip");
     bufsz = wcslen(zip_path);   /* Replace "00" with version */
     zip_path[bufsz - 6] = VERSION[0];
     zip_path[bufsz - 5] = VERSION[2];
@@ -712,7 +712,7 @@
             fprintf(stderr,
                 "Could not find platform dependent libraries <exec_prefix>\n");
         wcsncpy(exec_prefix, _exec_prefix, MAXPATHLEN);
-        joinpath(exec_prefix, L"lib/lib-dynload");
+        joinpath(exec_prefix, L"lib64/lib-dynload");
     }
     /* If we found EXEC_PREFIX do *not* reduce it!  (Yet.) */
 
diff -uar Python-3.5.1.orig/configure Python-3.5.1/configure
--- Python-3.5.1.orig/configure	2015-12-07 03:39:11.000000000 +0200
+++ Python-3.5.1/configure	2015-12-14 21:27:46.089400598 +0200
@@ -14464,7 +14464,7 @@
 $as_echo "$LDVERSION" >&6; }
 
 
-LIBPL='$(prefix)'"/lib/python${VERSION}/config-${LDVERSION}"
+LIBPL='$(prefix)'"/lib64/python${VERSION}/config-${LDVERSION}"
 
 
 # Check whether right shifting a negative integer extends the sign bit
diff -uar Python-3.5.1.orig/setup.py Python-3.5.1/setup.py
--- Python-3.5.1.orig/setup.py	2015-12-07 03:39:11.000000000 +0200
+++ Python-3.5.1/setup.py	2015-12-14 21:27:46.090400632 +0200
@@ -469,7 +469,7 @@
         # directories (i.e. '.' and 'Include') must be first.  See issue
         # 10520.
         if not cross_compiling:
-            add_dir_to_list(self.compiler.library_dirs, '/usr/local/lib')
+            add_dir_to_list(self.compiler.library_dirs, '/usr/local/lib64')
             add_dir_to_list(self.compiler.include_dirs, '/usr/local/include')
         # only change this for cross builds for 3.3, issues on Mageia
         if cross_compiling:
@@ -750,11 +750,11 @@
             elif curses_library:
                 readline_libs.append(curses_library)
             elif self.compiler.find_library_file(lib_dirs +
-                                                     ['/usr/lib/termcap'],
+                                                     ['/usr/lib64/termcap'],
                                                      'termcap'):
                 readline_libs.append('termcap')
             exts.append( Extension('readline', ['readline.c'],
-                                   library_dirs=['/usr/lib/termcap'],
+                                   library_dirs=['/usr/lib64/termcap'],
                                    extra_link_args=readline_extra_link_args,
                                    libraries=readline_libs) )
         else:
@@ -791,8 +791,8 @@
             if krb5_h:
                 ssl_incs += krb5_h
         ssl_libs = find_library_file(self.compiler, 'ssl',lib_dirs,
-                                     ['/usr/local/ssl/lib',
-                                      '/usr/contrib/ssl/lib/'
+                                     ['/usr/local/ssl/lib64',
+                                      '/usr/contrib/ssl/lib64/'
                                      ] )
 
         if (ssl_incs is not None and
